Purified anti-human CD135 (Flt-3/Flk-2);Isotype:Mouse IgG1, κ;Reactivity:Human;Clone#:BV10A4H2;Appli-PF

Purified anti-human CD135 (Flt-3/Flk-2);Isotype:Mouse IgG1, κ;Reactivity:Human;Clone#:BV10A4H2;Appli 分享给好友：
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Description	CD135 is a 130-160 kD type III tyrosine kinase receptor expressed on CD34⁺ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc.
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Recommended Usage	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 microg per 10 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.
References	1. Broudy VC, et al. 1999. Blood 94:1979. (IF, IP) 2. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 3. Nagano M, et al. 2007. Blood 110:151. (FC) PubMed

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