Purified anti-human CD220；Clone#：B6.220Host/Isotype：Mouse IgG2b, κ
详细描述
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 Human peripheral blood monocytes were stained with purified CD220 (clone B6.220) (filled histogram) or mouse IgG2b, κ isotype control, followed by biotinylated anti-mouse IgG and Sav-PE (open histogram). |
| Description: |
CD220, also known as insulin receptor, is a type I transmembrane receptor tyrosine kinase composed of two extracellular α-subunits and two transmembrane β-subunits. Binding insulin, the insulin receptor forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. Activation of insulin receptor leads to subsequent downstream signaling in metabolic regulation, inducing glucose uptake, cell growth, differentiation, and apoptosis. Gene mutation in the insulin receptor or decreased insulin receptor signaling leads to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus (diabetes mellitus type 2). Most normal cells constitutively express insulin receptors. In hematopoietic cells, insulin receptor is constitutively expressed on monocytes and selectively expressed on activated lymphocytes. |
| Other Names: |
Insulin Receptor |
| Structure: | Consist of two alpha subunits and two beta subunits; the beta subunit passes through the cellular membrane and is linked by disulfide bonds. |
| Distribution: | Hematopoietic and non hematopoietic cells. |
| Function: | Regulates cell metabolism and growth. |
| Ligand Receptor: | Insulin |
| Interaction: | Ectonucleotide pyrophosphatase/phosphodiesterase, PTPN11, GRB10, GRB7, PRKCD, IRS1, SH2B1 and Mothers against decapentaplegic homolog 2. |
| Antigen References: |
1. Viardot A, et al. 2006. Endocrinology 148:346. |
