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Recombinant Mouse IL-20 Protein (25 UG)
详细描述
Source:E. coli-derived, Leu25-Leu176, with an N-terminal Met
Accession #:Q9JKV9.1
N-terminal Sequence Analysis:Met
Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Predicted Molecular Mass:17.7 kDa
Activity:Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human IL-20 R alpha and human IL-20 R beta.
The ED50 for this effect is typically 0.5 - 2.5 ng/mL.
The ED50 for this effect is typically 0.5 - 2.5 ng/mL.
Molecule Information:
IL-20
Long Name:
Interleukin 20
Entrez Gene IDs:
50604 (Human); 58181 (Mouse)
Background:
IL-20
Mature human and mouse IL-20 is a 152 amino acid protein that is not likely glycosylated. Although IL-20 is a distant member of the IL-10 family, it functions as a monomer. IL-20 binds two heterodimeric receptor complexes, IL-20 R alpha/IL-20 R beta and IL-22 R/IL-20 R beta. IL-20 is reported to induce the proliferation of multipotential hematopoietic progenitor cells, direct the differentiation and expansion of keratinocytes, and promote the release of proinflammatory mediators in keratinocytes and other IL-20 receptor-expressing cells.
Mature human and mouse IL-20 is a 152 amino acid protein that is not likely glycosylated. Although IL-20 is a distant member of the IL-10 family, it functions as a monomer. IL-20 binds two heterodimeric receptor complexes, IL-20 R alpha/IL-20 R beta and IL-22 R/IL-20 R beta. IL-20 is reported to induce the proliferation of multipotential hematopoietic progenitor cells, direct the differentiation and expansion of keratinocytes, and promote the release of proinflammatory mediators in keratinocytes and other IL-20 receptor-expressing cells.
