Overview

• Product nameAnti-TSH [057-11005] antibodySee all TSH primary antibodies ...
• Description
  Mouse monoclonal [057-11005] to TSH
• SpecificityCross reactivity: TSH 100%, hCG 0.0%, LH 2.1%, FSH 1.0%
• Tested applicationsSandwich ELISA, SDS-PAGE more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  TSH from Human pituitary gland.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.40
  Constituents: 0.14% Sodium phosphate, 0.88% Sodium chloride
• Concentration information loading...
• PurityDEAE-Chromatography
• Purification notesab130758 is purified from Mouse ascites, and is >80% pure (SDS-PAGE). DEAE chromatography. The product is 0.2 µm filtered.
• Clonality Monoclonal
• Clone number057-11005
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Neuroscience
  • Endocrine system
  • Thyroid axis

  • Cancer
  • Growth factors
  • Hormones

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

Applications

Target

• RelevanceThyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
• Cellular localizationSecreted
• Database links
  • Entrez Gene: 1081 Human
  • Entrez Gene: 7252 Human
  • Omim: 118850 Human
  • Omim: 188540 Human
  • SwissProt: P01215 Human
  • SwissProt: P01222 Human
• Alternative names
  • Anterior pituitary glycoprotein hormones common subunit alpha antibody
  • CG ALPHA antibody
  • CGA antibody

  • CGA protein antibody
  • Choriogonadotropin alpha chain antibody
  • Chorionic gonadotrophin alpha subunit antibody
  • Chorionic gonadotropin alpha polypeptide antibody
  • Follicle stimulating hormone alpha chain antibody
  • Follitropin alpha chain antibody
  • FSH alpha antibody
  • FSHA antibody
  • Glycoprotein hormones alpha chain antibody
  • Glycoprotein hormones alpha polypeptide antibody
  • GPHa antibody
  • GPHA1 antibody
  • HCG antibody
  • LHA antibody
  • LSH alpha antibody
  • Luteinizing hormone alpha chain antibody
  • Lutropin alpha chain antibody
  • Thyroid stimulating hormone alpha chain antibody
  • Thyroid stimulating hormone antibody
  • Thyroid stimulating hormone beta antibody
  • Thyroid stimulating hormone beta subunit antibody
  • Thyroid stimulating hormone subunit beta antibody
  • Thyroid Stimulation Hormone antibody
  • Thyrotropin alfa antibody
  • Thyrotropin alpha chain antibody
  • Thyrotropin antibody
  • Thyrotropin beta subunit antibody
  • Thyrotropin subunit beta antibody
  • TSH A antibody
  • TSH alpha antibody
  • TSH B antibody
  • TSH beta antibody
  • TSHA antibody
  • TSHB antibody

  see all