Corning Hepatocyte Maintenance Medium is designed for the in vitro cultivation and maintenance of hepatocytes for research applications, drug discovery and studies related to preclinical drug induced liver injury. This specialized medium is optimized to maintain the physiological relationships between hepatic Phase I and II drug metabolism enzymes, influx and efflux transporters, and meet the long-term high metabolic needs of hepatocytes. Corning Hepatocyte Maintenance Medium is defined, animal-origin free and serum-free and optimized for primary human hepatocytes.